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From the Staff at Physician.com
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Phase IIa Clinical Trial Results Relating To CK-1827452 In Patients With Ischemic Cardiomyopathy And Angina
Cytokinetics, Incorporated (NASDAQ: CYTK) announced today top-line results from a Phase IIa clinical trial evaluating the safety of CK-1827452 in patients with ischemic cardiomyopathy and angina. The primary safety endpoint was defined as stopping an exercise test during treatment with CK-1827452 (versus placebo) due to unacceptable angina at an earlier exercise stage than at baseline.
Hormones Increase Frequency Of Inherited Form Of Migraine In Women
Familial hemiplegic migraine (FHM) is an inherited form of severe migraine that is accompanied by visual disturbances known as aura. As with other types of migraine, it affects women more frequently than men. Most cases of FHM are caused by mutations in the CACNA1A gene, but whether these lead to spreading depression, the event in the brain that suppresses nerve cell activity and that has been linked to nongenetic forms of migraine with aura, has not been determined.
Addex Starts A Phase IIb Trial Of ADX10059 For Migraine Prevention
Addex Pharmaceuticals (SWISS: ADXN), the allosteric modulation company, announced the start of a Phase IIb trial of ADX10059 as a migraine prevention therapy in people who suffer from 3 or more migraine attacks per month. ADX10059 is a first-in-class migraine prophylactic which works by inhibiting the metabotropic glutamate receptor 5 (mGluR5) through negative allosteric modulation (NAM). Addex believes mGluR5 may be a key player in a neural process that initiates migraine headaches.
Help For Children And Teenagers Who Suffer From Migraines
Chocolate, excitement and the stress of Christmas: these are not just a headache for parents. They are also responsible for triggering migraines in many young people. Learning how to manage stress and avoid triggers are just as important as getting the right medication.
Telcagepant Proven As A Safe And Effective Migraine Treatment In Phase III Trial
Telcagepant 300 mg is effective as an acute treatment for migraine with efficacy comparable to that of zolmitriptan 5 mg, a widely-used migraine treatment, but with fewer associated adverse effects. These are the conclusions of an Article published Online first and in and upcoming edition of The Lancet, written by Dr Tony Ho, Merck Research Laboratories, North Wales, Philadelphia, USA, and colleagues.
Patent Foramen Ovale Closure Extremely Promising For Stroke Prevention And Treatment Of Migraine
There continues to be a disagreement between the neurological and vascular communities as to when to close the PFO (Patent Foramen Ovale) - the hole in the heart between the right and left atria): the former state that it should be done only after the occurrence of the second stroke, with anticoagulation medicines administered after the first stroke, and this is currently the prevailing practice.
Overuse Of Narcotics And Barbiturates May Make Migraine Worse
A team of researchers led by investigators at the Albert Einstein College of Medicine of Yeshiva University has determined that certain commonly-prescribed medications may have the unintended consequence of increasing the frequency of migraine attacks. This important finding could alter the way doctors prescribe migraine medicines.
1 In 4 Gulf War Veterans Suffer From Illness Caused By Toxic Exposure
At least one in four of the 697,000 U.S. veterans of the 1991 Gulf War suffer from Gulf War illness, a condition caused by exposure to toxic chemicals, including pesticides and a drug administered to protect troops against nerve gas, and no effective treatments have yet been found, a federal panel of scientific experts and veterans concludes in a landmark report released Monday.
500-Patient Study Measuring Cognitive Processing Efficiency During Migraine Attacks
PHT Corporation, the market-leading provider of electronic patient reported outcome (ePRO) solutions used in more than 360 clinical trials worldwide, is providing its innovative LogPad(R) System to help headache experts at Clinvest Clinical Research measure cognitive deficits during migraine attacks in a sponsored clinical trial. This is the first time cognitive processing time has been tested in a major migraine research study.
Breakthrough's Comment On Research Suggesting Women Who Have Migraines Have A Reduced Risk Of Breast Cancer
Research to be published in Cancer Epidemiology, Biomarkers and Prevention suggests that women who suffer from migraines may have a reduced risk of developing certain types of breast cancer. Dr Sarah Cant, Policy Manager at Breakthrough Breast Cancer, says: "This small study is the first to suggest that women who suffer migraines may have a reduced risk of developing certain types of breast cancer, so needs to be backed up by further research.
Pycnogenol Cut Jetlag Symptoms In Half For Passengers Taking 7- To 9-hour Flights
A new study published in the journal of Minerva Cardioangiologica reveals Pycnogenol, pine bark extract from the French maritime pine tree, reduces jetlag in passengers by nearly 50 percent. The two-part study, consisting of a brain CT scan and a scoring system, showed Pycnogenol lowered symptoms of jetlag such as fatigue, headaches, insomnia and brain edema (swelling) in both healthy individuals and hypertensive patients.
Women Who Have Migraines Have Lower Breast Cancer Risk
Women who suffer from migraines may take at least some comfort in a recent, first-of-its-kind study that suggests a history of such headaches is associated with a significantly lower risk of breast cancer. Christopher I. Li, M.D., Ph.D., and colleagues at Fred Hutchinson Cancer Research Center report these findings in the November issue of Cancer Epidemiology, Biomarkers and Prevention.
Doctors Stress Pressing Need For Research Into The Best Treatment For Medication Overuse Headaches
There is a critical need to review current treatment strategies for the increasingly common problem of medication overuse headaches (MOH), according to a series of international papers in the November issue of Cephalalgia. "MOH is associated with severe disability, unmet treatment need and little clinical data to support current management strategies" says neurology expert Professor David W Dodick from the Mayo Clinic College of Medicine, Arizona, USA.
Minster Pharmaceuticals Plc Announces Positive Results From Phase II Trial Of Migraine With Aura
Minster Pharmaceuticals plc (AIM: MPM), the drug development company specializing in neurological and psychiatric disorders, is pleased to announce positive results from its Phase II trial in Denmark of tonabersat in the prevention of migraine with aura. The median number of aura attacks was reduced by 68% (p=0.01) in patients receiving tonabersat when compared with placebo.
Targeting Neuropeptides Could Be Future For Migraine Treatment
Targeting a system which utilises peptides in the brain during a migraine could be the future of treatment for this debilitating condition. The future and recent developments in the field of migraine are discussed in a Comment in this week's edition of The Lancet, written by Dr Stephen D Silberstein, Thomas Jefferson University, Philadelphia, PA, USA.
Chronic Migraines Caused By A Hole In The Heart? "Highly Likely," New Research Says
New research unveiled at TCT 2008 by Dr. Stephen Silberstein (a leading neurologist) suggests that 66 percent of chronic migraine sufferers have abnormal blood flow caused by a hole in their heart or a right-to-left shunt that bypasses the filtration process of the lungs. Most of these defects are known as a PFO, a heart condition prior research shows is found in 25 percent of the population.
Migraine Action Plan Could Help Millions Of Sufferers Find A Positive Way Out Of Migraine
Migraines can be a debilitating condition and affect around 15% of the UK population, over 70% of whom are women. Recent research undertaken by Imigran Recovery reveals that over 81% of migraine sufferers cannot always control their migraine attacks while 71% say migraines leave them unable to function. For the 81% who are unable to control their migraines, a new interactive tool www.migraineactionplan.co.uk has been developed.
Pain In Chronic Headache Alleviated By Nerve Stimulation Therapy
A novel therapy using a miniature nerve stimulator instead of medication for the treatment of profoundly disabling headache disorders improved the experience of pain by 80-95 percent, according to a new study from the University of California, San Francisco and the National Hospital for Neurology and Neurosurgery in London.
Ulcerative Colitis/Stercoralis Infection
Although exacerbation of UC usually poses little diagnostic dilemma, physicians should remain cognizant to the possibility of an alternative cause for patient symptoms. An article published in the World Journal of Gastroenterology addresses this report. The research team led by Prof.
Children With Hay Fever More Likely To Experience Headaches, Facial Pain
Children who suffer from bouts of allergic rhinitis (hay fever) are also more likely to suffer from headaches, facial pain, and ear aches than children without these allergies, says new research presented at the 2008 American Academy of Otolaryngology - Head and Neck Surgery Foundation (AAO-HNSF) Annual Meeting & OTO EXPO in Chicago, IL. Allergic rhinitis is a collection of symptoms predominantly in the nose and eyes, caused by airborne particles of dust, dander, or plant pollens.
Migraine Research Foundation Announces Winners Of Grants To Spur Innovation In Migraine Research
The Migraine Research Foundation (MRF), the largest nonprofit funder of migraine research in the United States, today announced the winners of its second round of grants intended to spur innovation in migraine research. The grants totaled $200,000. The grantees were screened by MRF's medical advisory board, which is composed of leading scientists and clinicians from across the country.
Migraine Linked To Blood Clots In Veins
People with migraines may also be more likely to develop blood clots in their veins, according to a study published in the September 16, 2008, issue of Neurology®, the medical journal of the American Academy of Neurology. In the condition, called venous thrombosis or thromboembolism, blood clots form in a vein, which can limit blood flow and cause swelling and pain. Those clots can then dislodge from the vein and travel to the heart and the lungs, which can be fatal.
Oral CGRP Receptor Antagonist Showed Statistically Significant Improvement In Migraine Relief Versus Placebo
Merck Sharp & Dohme Limited announced that in a Phase III clinical trial telcagepant (formerly known as MK-0974) - an investigational oral calcitonin gene-related peptide (CGRP) receptor antagonist - significantly relieved moderate-to-severe migraine attacks, including migraine pain and migraine-associated symptoms, compared to placebo. In addition, the overall rates of adverse events in this trial were similar for telcagepant and placebo.
Migraine With Aura May Be Linked To Increased Risk Of Stroke And Heart Attacks And Must Be Taken Seriously By GPs
Doctors need to pay special attention to people with migraine with aura as they could be at increased risk of stroke or heart attack, a London conference heard today. Professor Tobias Kurth, a leading neuroepidemiologist from Harvard Medical School, USA, has found the links between migraine with aura and cardiovascular events are now so strong that GPs need to take them seriously.
Phase II Results Of COL-144 Presented At European Headache And Migraine Trust International Congress 2008
CoLucid Pharmaceuticals, Inc., an innovative biotechnology company focusing on therapies for central nervous system disorders, announced Phase II results of its lead compound COL-144 in the treatment of acute migraine. Results demonstrated that COL-144 was safe and effective in relieving migraine headaches. COL-144 is a first-in-class Neurally Acting Anti- Migraine Agent (NAAMA), which unlike triptans, exhibits anti-migraine activity without causing vasoconstriction.
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FDA Approves Drug For Patients With Advanced Prostate Cancer
The U.S. Food and Drug Administration recently approved the injectable drug degarelix, the first new drug in several years for prostate cancer. Degarelix is intended to treat patients with advanced prostate cancer. It belongs to a class of agents called gonadotropin releasing hormone (GnRH) receptor inhibitors. These agents slow the growth and progression of prostate cancer by suppressing testosterone, which plays an important role in the continued growth of prostate cancer.
Study Demonstrates That AHCC(R) Enhances Immune System By Increasing The Production Of Key Dendritic Cells
A recently published study in Nutrition and Cancer (60(5), 643-651) by researchers at Kansai Medical University in Osaka, Japan has shown that AHCC (Active Hexose Correlated Compound) enhances immune function by increasing the number of dendritic cells (DCs). DCs are a key part of the immune system responsible for presenting foreign substances to other immune system cells.
Differentiating Between Healthy Cells And Cancer Cells
One of the current handicaps of cancer treatments is the difficulty of aiming these treatments at destroying malignant cells without killing healthy cells in the process. But a new study by McMaster University researchers has provided insight into how scientists might develop therapies and drugs that more carefully target cancer, while sparing normal healthy cells Mick Bhatia, scientific director of the McMaster Stem Cell and Cancer Research Institute in the Michael G.
Discovery Of 'Relocation' Plan Of Metastatic Cancer Cells
Few things are as tiresome as house hunting and moving. Unfortunately, metastatic cancer cells have the relocation process down pat. Tripping nimbly from one abode to another, these migrating cancer cells often prove far more deadly than the original tumor. Although little has been known about how these rogue cells choose where to put down roots, researchers at the Stanford University School of Medicine have now learned just how nefarious they are.
"On Switch" For Cell Death Signaling Mechanism Discovered By Burnham Researchers
Scientists at Burnham Institute for Medical Research (Burnham) have determined the structure of the interactions between proteins that form the heart of the death inducing signaling complex (DISC), which is responsible for triggering apoptosis (programmed cell death). The research, performed by Stefan Riedl, Ph.D., and colleagues, published online on Dec.
Improved Understanding Of Complex Mechanisms That Regulate DNA Damage Control And Replication In The Cell Cycle
Scientists at Burnham Institute for Medical Research (Burnham) have demonstrated important new roles for the protein kinase complex Cdc7/Dbf4 or Cdc7/Drf1 (Ddk) in monitoring damage control during DNA replication and reinitiating replication following DNA repair. Since Ddk is often deregulated in human cancers, this new understanding of its role in DNA damage control could help shape new cancer therapies. The research was published in the
Treadmill Desks More Effective In Cancer Prevention For Women Than Vitamin C, E And Beta Carotene Supplementation
Yet another study published online by the Journal of the National Cancer Institute confirmed that vitamin supplementation provided no statistically significant value in cancer prevention among women. This study comes on the heels of numerous studies which all draw the same conclusion: vitamin supplementation among a normally well nourished population has no positive effect on cancer prevention.
New Insight Into Aggressive Childhood Cancer
A new study reveals critical molecular mechanisms associated with the development and progression of human neuroblastoma, the most common cancer in young children. The research, published by Cell Press in the January 6th issue of the journal Cancer Cell, may lead to development of future strategies for treatment of this aggressive and unpredictable cancer.
Inflammatory Breast Cancer: A Complex Disease
This article reviews the following: "Molecular Determinants of the Inflammatory Breast Cancer Phenotype".
21st Century Challenge Of Ovarian Cancer In The Elderly, A Personal Perspective - Cancernetwork.com
The incidence of ovarian cancer is highest in women over 70 years old, and the disease is the leading cause of death from gynecologic malignancies in the United States and Europe. Nevertheless, improving the quality of medical care for elderly women with ovarian cancer continues to be a challenge.
New Hope For Cancer Comes Straight From The Heart
Digitalis-based drugs like digoxin have been used for centuries to treat patients with irregular heart rhythms and heart failure and are still in use today. In the Dec. 16 issue of the Proceedings of the National Academy of Sciences, researchers at the Johns Hopkins University School of Medicine now report that this same class of drugs may hold new promise as a treatment for cancer. This finding emerged through a search for existing drugs that might slow or stop cancer progression.
2nd Eastern Mediterranean Meeting Of The European Association Of Urology Expected To Highlight Cystectomy
Because the 1st Eastern Mediterranean Meeting (EMM), which was held in Antalya (TR) in 2007, was a great success the 'second edition' will be organised on 23 and 24 January 2009 in the Pyramisa hotel in Cairo (EG). Approximately 250 participants from the eastern Mediterranean area are expected to participate.
Cancer Cells Escape Chemo Induced Cell Death
Scientists found that cancer cells were able to escape the programmed cell death induced by chemotherapy once the chemicals were removed: in fact even though the normal cell death process had started, they were able to recover, as long as they did not go beyond the end stage of normal "apoptosis", the natural process through which cells kill themselves when they receive a signal to do so.
Team Finds Breast Cancer Gene Linked To Disease Spread
A team of researchers at Princeton University and The Cancer Institute of New Jersey has identified a long-sought gene that is fatefully switched on in 30 to 40 percent of all breast cancer patients, spreading the disease, resisting traditional chemotherapies and eventually leading to death.
Molecular Determinants Of The Inflammatory Breast Cancer Phenotype
Despite advances in multimodality treatment, inflammatory breast cancer (IBC) remains the most aggressive and lethal form of breast cancer. The use of primary human IBC cell lines and functional in vivo xenograft cancer models have revealed characteristics innate to IBC thought to confer a strong metastatic potential and aggressive phenotype.
Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor Of CK2
Cylene Pharmaceuticals announced that it has initiated a Phase I clinical trial of its oral CK2 protein kinase inhibitor, CX-4945, in patients with advanced solid tumors, Castleman's disease, or multiple myeloma. The primary endpoints of the oral dose escalating trial are determination of safety, tolerance and PK properties of CX-4945 and to select the appropriate dose for Phase II trials.
Gene Helps Breast Cancer Spread And Resist Chemo
Scientists in the US looking for genomic changes in breast tumor samples found that a gene called metadherin (MTDH) appears to play a dual role in both helping cancer spread (metastasis) and maintain resistance to chemotherapy. They said this research identifies MTDH as an important new target for the treatment of high risk breast cancers.
Immutep Announces Positive Interim Results In Phase I/II Chemoimmunotherapy Trial In Breast Cancer
Immutep S.A. announced today interim results from its ongoing Phase I/II chemoimmunotherapy clinical trial in metastatic breast carcinoma. ImmuFact IMP321 was administered the day after weekly paclitaxel for six months. The interim results show a clinical response rate of 50 per cent compared to 25 per cent with paclitaxel alone. In addition, a robust immune response was observed in clinically-responding patients.
Study Links Obesity To Elevated Risk Of Ovarian Cancer
A new epidemiological study has found that among women who have never used menopausal hormone therapy, obese women are at an increased risk of developing ovarian cancer compared with women of normal weight. Published in the February 15, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the research indicates that obesity may contribute to the development of ovarian cancer through a hormonal mechanism.
Earlier, Individualized Treatment Of Thyroid Cancer Enabled By Molecular Imaging
In a study to determine the diagnostic value of molecular imaging in nodal staging of patients with thyroid cancer, researchers were able for the first time to accurately distinguish between cancerous cells in regional lymph nodes and normal residual thyroid tissue directly after surgery.
Novel Glioblastoma Mouse Model Developed By Salk Researchers
Researchers at the Salk Institute for Biological Studies have developed a versatile mouse model of glioblastoma - the most common and deadly brain cancer in humans - that closely resembles the development and progression of human brain tumors that arise naturally. "Mouse models of human cancer have taught us a great deal about the basic principles of cancer biology," says Inder Verma, Ph.D., a professor in the Laboratory of Genetics.
Dormant Cancer Cells Rely On Cellular Self Cannibalization To Survive
A single tumor-suppressing gene is a key to understanding, and perhaps killing, dormant ovarian cancer cells that persist after initial treatment only to reawaken years later, researchers at The University of Texas M. D. Anderson Cancer Center report in the December Journal of Clinical Investigation. The team found that expression of a gene called ARHI acts as a switch for autophagy, or self-cannibalization, in ovarian cancer cells.
Scientists Pull Protein's Tail To Curtail Cancer
When researchers look inside human cancer cells for the whereabouts of an important tumor- suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells' membranes and foiling cancer growth.
Johns Hopkins Scientists Pull Protein's Tail To Curtail Cancer
When researchers look inside human cancer cells for the whereabouts of an important tumor-suppressor, they often catch the protein playing hooky, lolling around in cellular broth instead of muscling its way out to the cells' membranes and foiling cancer growth.
Writing Chemotherapy Orders On The Day Of Administration And Improved Communication Could Reduce Medication Errors
Seven percent of adults and 19 percent of children taking chemotherapy drugs in outpatient clinics or at home were given the wrong dose or experienced other mistakes involving their medications, according to a new study led by Kathleen E. Walsh, MD, assistant professor of pediatrics at the University of Massachusetts Medical School, and published in the January 1, 2009 issue of the Journal of Clinical Oncology.
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Using Chronic Care Model Helps To Improve People's Health And Care
Ed Wagner, MD, MPH, knew there had to be a better way. He and Group Health colleagues set out 15 years ago to explore how best to engage patients with chronic diseases in effective care. With Robert Wood Johnson Foundation support, they developed the Chronic Care Model. More than 1,500 U.S. and international medical practices have adopted the Model. Now the largest roundup of evidence on how the Model performs in practice confirms that it works.
Controlling Type 2 Diabetes With Low-Carb Diets
In a six-month comparison of low-carb diets, one that encourages eating carbohydrates with the lowest-possible rating on the glycemic index leads to greater improvement in blood sugar control, according to Duke University Medical Center researchers.
Mental Functioning Slowed By Adult-Onset Diabetes With Deficits Appearing Early
Adults with diabetes experience a slowdown in several types of mental processing, which appears early in the disease and persists into old age, according to new research. Given the sharp rise in new cases of diabetes, this finding means that more adults may soon be living with mild but lasting deficits in their thought processes. A full analysis appears in the January issue of Neuropsychology, which is published by the American Psychological Association.
Inflammatory Factors And Diabetic Macular Edema Highlighted In Ophthalmology Jan. 2009
With a new study from the Centers for Disease Control and Prevention predicting that diabetic retinopathy will triple from 5.5 million in 2005 to 16 million in 2050, improved treatments are urgently needed for this leading cause of blindness in working-age people. The CDC study is the latest indicator of a world-wide diabetes epidemic that is motivating ophthalmic research around the globe.
Similar Long-term Mortality Risks In Men With Type 2 Diabetes And Men With Cardiovascular Disease
Men with type 2 diabetes and men with previous heart attack or stroke had a 3 to 4 fold risk of cardiovascular death compared to men without either disease in the years following the first acute event, according to a study in CMAJ.
One Person Diagnosed With Diabetes Every Three Minutes In The UK
One person is diagnosed with diabetes every three minutes* in the UK, according to new figures from Diabetes UK. The leading health charity, which has released the shocking statistic to mark its 75th Anniversary, says the number of people diagnosed with the condition is growing faster than ever. This is particularly worrying for Black and minority ethnic groups as Type 2 diabetes is up to three times more common in Black people and up to six times more common in South Asian people.
Cytomegalovirus: Cell Death May Bring New Life To Treatment Of Retinal Disease
Just days after the first retinal cell gets infected with the common cytomegalovirus, contiguous cells start committing suicide and researchers believe their death may provide clues to better treatment of this potentially blinding infection. Understanding the cell death may also provide new insight into the larger issue of how the retina responds to assault, whether by infection or a disease process such as diabetes, said Dr.
Andromeda Biotech Announces Successful Phase III Interim Results Of Its Lead Product, DiaPep277 For Type 1 Diabetes
Andromeda Biotech, a subsidiary of Clal Biotechnology Industries (CBI), focused on the development of innovative treatment for autoimmune diabetes announces positive results following the Phase III interim analysis for the company's lead product, DiaPep277 for the treatment of Type 1 diabetes.
100,000 People With Diabetes Call '999' A Year
People with diabetes made more than 100,000 emergency calls in the UK last year, according to Diabetes UK. The charity warns that although the ambulance service has recently experienced an unprecedented volume of calls with many for non-emergency situations, most calls from people with diabetes are for severe hypoglycaemia (hypo).
Expanding Festive Waistlines Put Thousands At Risk Of Type 2 Diabetes
Over-indulgence in too many calorific treats such as mince pies (around 200 calories each), Christmas cake (approximately 250 calories per slice) and mulled wine (about 250 calories in a glass) can leave us all struggling to buckle our belts in the New Year. Having a large waist means you are up to eleven times more likely to develop Type 2 diabetes and being overweight or obese is one of the strongest risk factors for developing Type 2 diabetes.
Innovative Gene Therapy Approach To Prevent Amputations In Patients Suffering Severe Peripheral Artery Disease
Cardiologists at Rush University Medical Center are studying an investigational medication to prevent amputations in patients suffering the most severe form of peripheral arterial disease. The study involves use of a highly innovative gene therapy approach to promote new blood vessel growth in the legs of patients with critical limb ischemia.
Diamyd Medical: New Study Application To Vaccinate Against Juvenile Diabetes With Diamyd®
Diamyd Medical AB (publ.) (Pink Sheets:DMYDY) (STO:DIAMB): A renowned research group at Lund University has filed an application with the Swedish Medical Products Agency to carry out a study of the diabetes vaccine Diamyd® for the prevention of type 1 diabetes in Swedish children. This is the second prevention study with the diabetes vaccine Diamyd® for which approval has been sought in a short period.
Updated Labelling For Diabetes Drug Actos And Risk Of Heart Failure, Canada
Health Canada is informing diabetic patients taking Actos (the brand name for the prescription drug pioglitazone hydrochloride) of recent changes to the prescribing information for this product. Health Canada has worked with the manufacturer to strengthen the labelling around heart failure and emphasize proper use.
Blood Sugar Linked To Decline Of Memory And Cognitive Health In Older People
US researchers examining how diseases in late life, such as stroke and diabetes, contribute to cognitive decline through their effect on the hippocampal region of the brain found that high blood sugar may contribute to the decline of memory and cognitive health in older people. They suggested exercising to improve blood sugar levels was a way some people might be able to delay the normal decline in memory and cognitive health that occurs in old age.
New Gene Found To Be Associated With Widely-used Marker Of Blood Glucose Concentration
Scientists have found that genetic variation at the hexokinase-1 gene is linked to variation in the blood concentration of glycated hemoglobin, an index of long-term blood glucose concentration widely used in the follow-up of diabetes patients. The study, conducted by researchers from the Brigham and Women's Hospital in Boston, USA, is published December 19 in the open-access journal PLoS Genetics.
Study Boosts Researchers' Hopes Of Using Osteocalcin To Treat Diabetes
Rube Goldberg-the cartoonist who devised complex machines for simple tasks-would have smiled at one of leptin's mechanisms for curbing insulin release. As Hinoi et al. show, the fat-derived hormone enlists the sympathetic nervous system to prevent bone-making cells from releasing a molecule that prods the pancreas to discharge insulin. The study appeared online December 22, 2008 (http://www.jcb.
Too Much Festive Food And Drink May Raise Your Risk Of Developing Diabetes Type 2
Excessive food and drink consumption over the festive period could increase your risk of developing Type 2 diabetes, leading health charity Diabetes UK warns today. Over-indulgence in too many calorific treats such as mince pies (around 200 calories each), Christmas cake (approximately 250 calories per slice) and mulled wine (about 250 calories in a glass) can leave us all struggling to buckle our belts in the New Year.
Reduction In Antibody Gene Rearrangement In B Cells Related To Type 1 Diabetes, Lupus
More drafts usually mean a better product and so it also seems to go with the human immune system. As B cells develop, genes rearrange to allow antibodies to recognize different foreign invaders or pathogens. But sometimes antibodies are created that recognize and attack the body's own cells. These self-reactive antibodies, like early drafts of a manuscript, must be edited into versions that won't attack self.
Treating Gum Disease Linked To Lower Medical Costs For Patients With Diabetes
A new report suggests that treating gum disease in patients who have diabetes with procedures such as cleanings and periodontal scaling is linked to 10 to 12 percent lower medical costs per month. The findings are encouraging but the study was not designed to firmly establish cause and effect, said George Taylor, University of Michigan associate professor of dentistry, who also has an appointment in epidemiology in the U-M School of Public Health.
ESC Statement On The Control Of Type 2 Diabetes
A study published by the Journal of the American Medical Association (JAMA) on 16 December 2008 has found that those with type 2 diabetes who had a diet high in low-glycemic foods such as nuts, beans and lentils had greater improvement in glycemic control and risk factors for coronary heart disease than those on a diet with an emphasis on high-cereal fibre.
Cellular Reprogramming: Science's Breakthrough Of The Year
In its annual list of the year's top ten scientific breakthroughs, the journal Science has given top honors to research that produced "made-to-order" cell lines by reprogramming cells from ill patients. These cell lines, and the techniques for producing them, offer long-sought tools for understanding -- and hopefully someday curing -- difficult-to-study diseases such as Parkinson's disease and type 1 diabetes.
Joint Statement From ACC, ADA And AHA Revises Recommendations For Glycemic Targets For Some Patients
Some people with diabetes may require less stringent glycemic control than previously recommended, but most should stick with the target goal of less than 7 percent long advised for reducing the risk of diabetes-related complications, according to a position statement issued joint
Type 1 Diabetes May Be Triggered By Common Infant Virus
Human parechovirus is a harmless virus which is encountered by most infants and displays few symptoms. Suspected of triggering type 1 diabetes in susceptible people, research methods need to take this "silent" virus into consideration. This comes from findings in a study from the Norwegian Institute of Public Health. This study was part of a long-term project at the Norwegian Institute of Public Health to investigate if environmental risk factors affect type 1 diabetes.
Study Shows Regular Exercise Might Prevent Onset Of Diabetes In Black Women
Taking a brisk walk several times a week for exercise appears to reduce black women's risk of developing type 2 diabetes, according to a study published this month in the American Journal of Epidemiology, Reuters Health reports. Few studies have been conducted on the benefits of exercise among black women, according to Reuters.
Putting Heart Into Diabetes And Coronary Care
A quarter of Type 2 diabetes patients admitted to hospital with a heart problem were readmitted within 28 days, compared to just six per cent of coronary patients who did not have diabetes, a Queensland University of Technology researcher has found. Dr Jo Wu, from the School of Nursing, discovered during her latest study that people who have diabetes and a heart condition often find it difficult to manage both conditions, leading to a high number of hospital readmissions.
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